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Estrogens increase thyroid-binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT 4 levels by column or by radioimmunoassay or T 3 levels by radioimmunoassayT 3 resin uptake is decreasedreflecting the elevated TBGFree T 4 and free T 3 concentrations are unaltered.
High levels of calcium in your bloodnauseavomitingconstipationincreased thirst or urinationmuscle weaknessbone painlack of energy.
Since large and repeated doses of estrogen over an extended time period have been shown to accelerate epiphyseal closurehormonal therapy should not be started before epiphyseal closure has occurred in order not to compromise final growth.
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