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Medrol should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

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Abdominal cramping and/or burningsevereabdominal pain backache bloodyblackor tarry stools cough or hoarseness darkening of skin decrease in height decreased vision diarrhea dry mouth eye pain eye tearing facial hair growth in females fainting fatigue fever or chills flusheddry skin fractures fruit-like breath odor full or round faceneckor trunk heartburn and/or indigestionsevere and continuousincreased hunger increased thirst increased urination loss of appetite loss of sexual desire or ability lower back or side pain menstrual irregularities muscle pain or tenderness muscle wasting or weakness nausea pain in backribsarmsor legs painful or difficult urination skin rash sleeplessness sweating trouble healing trouble sleeping unexplained weight loss unusual tiredness or weakness vision changes vomiting vomiting of material that looks like coffee grounds.

Frequency not reportedConvulsionsheadacheincreased intracranial pressure with papilledemapseudotumor cerebriusually following discontinuation of treatmentneuritisneuropathyparesthesiaamnesiadizzinessRef]

Frequency not reportedSuppression of growth in pediatric patientsaseptic necrosis of femoral and humeral headscalcinosisCharcot-like atrophyloss of muscle massmuscle weaknessosteoporosispathologic fracture of long bonespostinjection flaresteroid myopathytendon ruptureparticularly of the Achilles tendonvertebral compression fracturesmyalgiamuscle atrophyosteonecrosisneuropathic arthralgiagrowth retardationRef]

With therapeutically equivalent dosesthe likelihood of occurrence of troublesome side effects is less with methylprednisolone than with prednisolonemoreoverside effects actually have been conspicuously absent during clinical trials with MEDROL Tablets in dogs and catsHowevermethylprednisolone is similar to prednisolone in regard to kinds of side effects and metabolic alterations to be anticipated when treatment is intensive or prolongedIn animal patients with diabetes mellitususe of methylprednisolone may be associated with an increase in the insulin requirementNegative nitrogen balance may occurparticularly in animals that require protracted maintenance therapymeasures to counteract persistent nitrogen loss include a high protein intake and the administration when indicatedof a suitable anabolic agentExcessive loss of potassiumlike excessive retention of sodiumis not likely to be induced by effective maintenance doses of MEDROLHoweverthese effects should be kept in mind and the usual regulatory measures employed as indicatedEcchymotic manifestationswhile not noted during the clinical evaluation in dogs and catsmay occurIf such reactions do occur and are seriousreduction in dosage or discontinuance of methylprednisolone therapy may be indicatedConcurrent use of daily oral supplements of ascorbic acid may be of value in helping to control ecchymotic tendencies.

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pregnancy the use of medrol dose pack in dentistry should be avoided in pregnant woman since the risk outweight the benefit nursing mother corticosteroid appear in breast milk and could suppress growth, interfere with endogeneous steroid production, and cause other unwanted effect.

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