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Grapefruit juice may prevent the breakdown of erythromycin, resulting in elevated levels of erythromycin in the blood.

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For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseasesrespiratory tract infectionsupper and lowerof mild to moderate degreepertussiswhooping coughas adjunct to antitoxin in infections due to Corynebacterium diphtheriaein the treatment of infections due to Corynebacterium minutissimumintestinal amebiasis caused by Entamoeba histolyticaacute pelvic inflammatory disease caused by Neisseria gonorrhoeaeskin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureusprimary syphilis caused by Treponema palliduminfections caused by Chlamydia trachomatisnongonococcal urethritis caused by Ureaplasma urealyticumand Legionnairesdisease caused by Legionella pneumophila

Theophyllines such as theophyllineTheo-DuroxtriphyllineCholedyl SAand aminophyllinePhyllocontinreduce erythromycin blood levels by increasing elimination of erythromycin by the kidneyswhich may reduce the effectiveness of erythromycinConverselyerythromycin inhibits the metabolismbreakdownof theophyllines by the liver and causes an increase in blood levels of theophyllineHigh theophylline levels may give rise to side effects such as seizures and disturbances in heart rhythmThereforethe dose of theophyllines should be reduced or theophylline levels in the blood should be measured in patients taking erythromycin.

Take erythromycin exactly as prescribed by your doctorFollow all directions on your prescription label and read all medication guides or instruction sheetsYour doctor may occasionally change your doseUse the medicine exactly as directed.

Some medicines can cause unwanted or dangerous effects when used with erythromycinYour doctor may change your treatment plan if you also use:

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if you have diarrhea that is watery or bloody, stop taking erythromycin and call your doctor.

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