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CRESTOR is a selective and competitive inhibitor of HMG-CoA reductasethe rate-limiting enzyme that converts 3-hydroxy3methylglutaryl coenzyme A to mevalonatea precursor of cholesterolIn vivo studies in animalsand in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake intoand selectivity foraction in the liverthe target organ for cholesterol loweringIn in vivo and in vitro studiesrosuvastatin produces its lipid-modifying effects in two waysFirstit increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDLSecondrosuvastatin inhibits hepatic synthesis of VLDLwhich reduces the total number of VLDL and LDL particles.

When CRESTOR was coadministered with fenofibrateno clinically significant increase in the AUC of rosuvastatin or fenofibrate was observedBecause it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concomitant use of fenofibratescaution should be used when prescribing fenofibrates with CRESTORsee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY

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Take CRESTOR exactly as your doctor tells you to take itTake CRESTORby mouth1 time each daySwallow the tablet wholeCRESTOR can be taken at any time of daywith or without foodDo not change your dose or stop CRESTOR without talking to your doctoreven if you are feeling wellYour doctor may do blood tests to check your cholesterol levels before and during your treatment with CRESTORYour doctor may change your dose of CRESTOR if neededYour doctor may start you on a cholesterol lowering diet before giving you CRESTORStay on this diet when you take CRESTORWait at least 2 hours after taking CRESTOR to take an antacid that contains a combination of aluminum and magnesium hydroxideIf you miss a dose of CRESTORtake it as soon as you rememberHoweverdo not take 2 doses of CRESTOR within 12 hours of each otherIf you take too much CRESTOR or overdosecall your doctor or go to the nearest hospital emergency room right away.

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in 2008, medical researchers noticed that some patients who took the statin drug called crestor had higher levels of sugar in their blood.

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