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No dedicated pharmacokinetic study has been conducted using colchicine capsules in patients with varying degrees of renal impairmentColchicine is known to be excreted in urine in humans and the presence of severe renal impairment has been associated with colchicine toxicityUrinary clearance of colchicine and its metabolites may be decreased in patients with impaired renal functionDose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe renal impairmentColchicine is not effectively removed by hemodialysisPatients who are undergoing hemodialysis should be monitored carefully for colchicine toxicity.
Because of the increased incidence of decreased renal function in the elderly populationand the higher incidence of other co-morbid conditions in the elderly population requiring the use of other medicationsreducing the dosage of colchicine when elderly patients are treated with colchicine should be carefully considered.
Colchicine consists of pale yellow scales or powderit darkens on exposure to lightColchicine is soluble in waterfreely soluble in alcoholand slightly soluble in ether.
About all of your medical conditions if you have kidney or liver problems if you are pregnant or plan to become pregnantIt is not known if colchicine capsules can harm your unborn babyTalk to your healthcare provider if you are pregnant or plan to become pregnantif you are breastfeeding or plan to breastfeedColchicine can pass into your breast milk and may harm your babyTalk to your healthcare provider about the best way to feed your baby if you take colchicine capsules.
Musculoskeletalmyopathyelevated CPKmyotoniamuscle weaknessmuscle painrhabdomyolysis.
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in 2007, url pharma organized pharmacokinetic studies testing its version of colchicine in healthy volunteers and a randomized, controlled trial involving 185 patients with acute gout.
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