Simultaneous analysis of chloramphenicol and tetracycline extracted following the protocol of the european standard 150 mg mgso4, 25 mg psa , pdf antibiotic prophylaxis in prostate biopsy.
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Severe headachedizzinessblurred visionfeverchillsbody achesflu symptomssevere blisteringpeelingand red skin rashurinating less than usual or not at allpale or yellowed skindark colored urinefeverconfusion or weaknesssevere pain in your upper stomach spreading to your backnausea and vomitingfast heart rateloss of appetitejaundiceyellowing of the skin or eyesor easy bruising or bleedingunusual weakness.
Do not use this medication if you are allergic to tetracyclineor to similar medicines such as demeclocyclineDeclomycindoxycyclineAdoxaDoryxOraceaVibramycinor minocyclineDynacinMinocinSolodynVectrin
Avoid exposure to sunlight or artificial UV rayssunlamps or tanning bedsTetracycline can make your skin more sensitive to sunlight and sunburn may resultUse a sunscreenminimum SPF 15and wear protective clothing if you must be out in the sun.
TABLE IV Environmental concentration of antibiotics of the tetracycline family.
The most common mechanism by which microbes become resistant to tetracyclines is decreased accumulation of drug into previously susceptible organismsTwo mechanisms include 1impaired uptake into bacteriawhich occurs in mutant strains that do not have the necessary transport systemand 2the much more common plasmidor transposon-mediated acquisition of active efflux pumpsThe genomes for these capabilities may be transferred either by transductionas in Staphylococcus aureusor by conjugationas in many enterobacteriaA second mechanism of resistance is the production of aprotectiveprotein that acts by either preventing bindingdislodging the bound drugor altering the negative impact of binding on ribosomal functionAmong the tetracyclinestigecycline is characterized by less resistance due to efflux or ribosomal protectionRarelytetracyclines can be destroyed by acetylationResistance develops slowly in a multistep fashion but is widespread because of the extensive use of low concentrations of tetracyclines.
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tetracycline can cause side effects such as mild nausea, vomiting, diarrhea, headache, dizziness, vaginal itching, and mouth sores.
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