According to the instructions, lasix furosemide tablet is strictly forbidden to use .
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FDA-approved product labeling for many medications have included a broad contraindication in patients with a prior allregic reaction to sulfonamideshoweverrecent studies have suggested that crossreactivity between antibiotic sulfonamides and nonantibiotic sulfonamides is unlikely to occur.
Investigations into the mode of action of LASIX have utilized micropuncture studies in ratsstop flow experiments in dogs and various clearance studies in both humans and experimental animalsIt has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of HenleThe high degree of efficacy is largely due to the unique site of actionThe action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Methotrexate and other drugs thatlike LASIXundergo significant renal tubular secretion may reduce the effect of LASIXConverselyLASIX may decrease renal elimination of other drugs that undergo tubular secretionHigh-dose treatment of both LASIX and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of LASIX.
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such drugs include thiazide diuretics for example, hydrochlorothiazide microzide , loop diuretics for example, furosemide lasix , amphetamines, glucocorticoids such as prednisone and methylprednisolone medrol , estrogens, isoniazid, phenothiazines such as chlorpromazine thorazine , phenytoin dilantin , somatropin genotropin , decongestants and thyroid drugs.
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