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Well-known brands of the drugs – called proton pump inhibitors or ppis – include astrazeneca s nexium and prilosec.

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Several published observational studies suggest that proton pump inhibitorPPItherapy may be associated with an increased risk for osteoporosis-related fractures of the hipwristor spineThe risk of fracture was increased in patients who received high-dosedefined as multiple daily dosesand long-term PPI therapya year or longerPatients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treatedPatients at risk for osteoporosis-related fractures should be managed according to established treatment guidelinessee DOSAGE AND ADMINISTRATION and ADVERSE REACTIONS

Published observational studies suggest that PPI therapy like NEXIUM may be associated with an increased risk of Clostridium difficile associated diarrheaespecially in hospitalized patientsThis diagnosis should be considered for diarrhea that does not improvesee ADVERSE REACTIONS

NEXIUM is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulationHypersensitivity reactions may include anaphylaxisanaphylactic shockangioedemabronchospasmacute interstitial nephritisand urticariasee ADVERSE REACTIONS

Let patients know that antacids may be used while taking NEXIUMAdvise patients to take NEXIUM at least one hour before a mealFor patients who are prescribed NEXIUM Delayed-Release Capsulesadvise them not to chew or crush the capsulesAdvise patients thatif they open NEXIUM Delayed-Release Capsules to mix the granules with foodthe granules should only be mixed with applesauceUse with other foods has not been evaluated and is not recommendedFor patients who are advised to open the NEXIUM Delayed-Release Capsules before taking them or who are prescribed NEXIUM For Delayed-Release Oral Suspensioninstruct them in the proper technique for administrationsee DOSAGE AND ADMINISTRATIONand tell them to follow the dosing instructions in the PATIENT INFORMATION insert included in the packageInstruct patients to rinse the syringe with water after each useFor patients who are prescribed NEXIUM For Delayed-Release Oral Suspension and need to use more than one packet for their doseinstruct them regarding the correct amount of water to use when mixing their dose.

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