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The safety and efficacy of imuran for the treatment of crohn s disease and ulcerative colitis have not been established.

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Information about Imuran.

Long-term use may raise your chance of cancerLymphoma and other cancers have happened in people who take Imuranazathioprine tabletsor drugs like itThis has been deadly in some casesTalk with the doctorA rare type of cancer called hepatosplenic T-cell lymphomaHSTCLhas happened with Imuranazathioprine tabletsThese cases have been deadlyMost of the timethese cases happened in teenagers or young adultsMost of these patients were using Imuranazathioprine tabletsto treat certain types of bowel problems like Crohn disease and ulcerative colitisThis medicine is not approved for use to treat bowel problems like theseTell the doctor if you have ever had any type of cancerTalk with the doctor.

Imuran therapy should not be initiated in patients who may be pregnantor who are likely to become pregnant without careful assessment of risk versus benefitsee Special Warnings and Precautions for UsePregnancy and Lactation

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One of the pathways for inactivation of azathioprine is inhibited by allopurinolPatients receiving IMURAN and allopurinol concomitantly should have a dose reduction of IMURANto approximately 1/3 to 1/4 the usual doseIt is recommended that a further dose reduction or alternative therapies be considered for patients with low or absent TPMT activity receiving IMURAN and allopurinol because both TPMT and XO inactivation pathways are affectedSee CLINICAL PHARMACOLOGYWARNINGSPRECAUTIONSLaboratory Tests and ADVERSE REACTIONS sections.

Relatively oliguric patientsespecially those with tubular necrosis in the immediate postcadaveric transplant periodmay have delayed clearance of IMURAN or its metabolitesmay be particularly sensitive to this drugand are usually given lower doses.

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