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In the extended adjuvant setting for femara median duration of treatment 5 years and placebo median duration of treatment 3 years , respectively angina requiring surgery 0.

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The optimal duration of treatment with Femara is not knownTreatment should be discontinued if there is a tumor relapse.

Heart ProblemsThis medication may increase symptoms of decreased blood flow to the heart in women who have a history of a blockage in their arteriesIf you experience new or worsening chest pain or shortness of breath go to the emergency room immediately.

Adjuvantpost-surgerytreatment of hormone receptor positive invasive early breast cancerExtended adjuvant treatment of hormone-dependent invasive breast cancer in women who have received prior standard adjuvant tamoxifen therapy for five yearsFirst-line treatment for hormone-dependent advanced breast cancerAdvanced breast cancer after relapse or disease progressionin women with natural or artificially induced postmenopausal endocrine statuswho have previously been treated with anti-oestrogensNeo-adjuvantpre-surgerytreatment of hormone receptor positiveHER-2 negative breast cancer where chemotherapy is not suitable and immediate surgery not indicated.

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